Existing Treatments & the drawbacks (NIDDM)

Most of the existing drugs like sulphonyl urea's and biguanides used in the tretment of NIDDM, exert a lot of side affects viz. Severs hypoglycemia, hematological disorders, cholestatic jaundice, lactic-acidosis, severe weight gain or loss, cardiovascular complication and water retention, prolonged use of these drugs add to the cause of development of various kinds of neuropathies which further deteriorates the quality of life.
Clinical Trail Report

A clinical trail has been conducted to evaluate the efficacy of Episulin in the tretment of Non Insulin Dependent Diabetes Mellitus (NIDDM) at sir sunder Lal Hospital by Dr. K.N.Dwivedi, Consultant - Diabetic Clinic (I.M.), Institute of Medical Sciences, Banaras Hindu University, Varanasi. Dr K.N.Dwivedi is a member of Diabetic Association of India (DAI), Research Society for Study of Diabetes in India (RSSDI) and Indian Society of Wound Management (ISWM).

A number of diagnosed patient of Non Insulin dependent Diabetes Mellitus (NIDDM) were selected for present study from the out patient Department (OPD) and In-door of the diabetic clinic, (Indian Medicine), Sir Sunderlal Hospital, Institute of Medical Sciences, Banaras Hindu University, Varanasi.

All the patient were examined clinically for the signs and symptoms of diabetes Mellitus and subjected for routine Biochemical investigation as per clinical protocol. Self-control method was used in this clinical trail.

Follow - up Studies

All the patient were assessed on clinical and bio-chemical parameters periodically at the interval of one month , two month & three months.

PARAMETERS OF ASSESSMENT
Assessment was done on objective and subjective parameters.

Parameters of Objective assessment were:

·Reduction in Fasting and Post-Prandial Blood Sugar Level
· Desirable change in the status of Body Mass Index (BMI)
· Changes in Hemoglobin Level
· Changes in Levels of Serum Cholesterol
· Changes in Levels of blood Urea and Serum Creatinine Parameters of Subjective assessment were:
· The presence or absence of symptoms at the end of three months treatment.

DOSAGE
All the patient were given 1 Episulin capsule twice daily before meals.