The whole formulation of Episulin is based on an active principle 'Epicatechin' which is at the core of the total product. Other ingredients are added to prevent an care the different complication of diabetes. It controls the metabolic derangement's rather then mere control of blood sugar level.

Physiology & Pharmacology of Active Principles

The active principle of Episulin is Epicatechin, which is extracted from the bark of P.marsupium in a highly scientific manner. Epicatechin is a benzopyran having the following organic structure.

The active principle controls diabetes in the following manner:

A) Epicatechin increase the cAMP content of the islet which is associated with increased insulin release.

B) Epicatechin plays a role in the conversion of proinsulin to insulin by increasing cathepsin activity.

C) Epicatechin plays an insulin-mimetic effect on osmotic fragility of human erythrocytes.

D) Epicatechin inhibits Na/K ATPase activity on patient's erythrocytes, an effect similar to that of insulin.

Experimental Studies on Animals

Experimental studies of Episulin has been conducted on animals at Institute of Medical Sciences, B.H.U., Varanasi to establish the superiority of the imperial formulation over the singular use of Epicatechin (P.Marsupium).

Animals were divided into 2 groups. Group 1 animals were treated with P.Marsupium (2gm.) And group 2 animals were treated with Episulin.

It was observed that there is a lowering of blood sugar level in both the groups but the results are more pronounced in group 2 as compared to group 1. Thus indicating the synergistic action of the other ingredients of Episulin with P.Marsupium.

It has been clearly established by the findings of the experiment that although Epicatechin (P.Marsupium) showed results, but the results of imperical formulation was more prominent in lowering of blood sugar level as will as in improving the quality of life by controlling other peripheral problems.

This formulation offers: ·

The gentle hypoglycemic activity by natural ingredients · It corrects the neuropathy, retinopathy and disturbed metabolism of glucose and lipids. · It maintains the integrity of all organ system affected by the disease.

Indication & Usage

A) Curative for diabetes II (NIDDM)

B) Good adjuvant for IDDM, in order to reduce the amount of needed Insulin.

C) Advised along with existing oral hypoglycemic drugs.

D) Is preventive as will as curative for diabetic complication.

E) Is advised along with appropriate diet and exercise.

F) Is advised along with any integrated diabetes control programmed

G) Is gentle hypoglycemic in nature and hence induces no risk of hypoglycemic.